Super-resolution microscope for single-molecule research

ONI has launched the Aplo Scope, a single-molecule super-resolution microscope designed to capture and analyse molecular interactions with unmatched precision. This advanced system enables researchers to explore nanoscale biological structures in real-time, overcoming limitations of traditional imaging techniques.

The Aplo Scope provides a seamless transition from low-power live-cell imaging to high-resolution microscopy at 20 nm resolution, eliminating the need for complex hardware adjustments. Its compact benchtop design integrates cutting-edge imaging technology with automated workflows, allowing scientists to investigate cellular structures in depth and accelerate discoveries in drug delivery, biomarker identification, and antibody therapeutics.

“The future of biology and drug development depends on our ability to visualise molecular interactions with extraordinary clarity,” said Paul Scagnetti, CEO of ONI. “The Aplo Scope delivers the precision and speed required to unlock new insights, pushing the boundaries of what’s possible in medicine.”

Equipped with a custom-engineered laser module offering precise power control (0.01 kW/cm² to 4.0 kW/cm²), the Aplo Scope enables effortless shifts between live-cell imaging and super-resolution at the click of a button. Its advanced filter set and intuitive software simplify complex assays such as multi-colour imaging and time-lapse studies of biological processes.

Researchers worldwide recognise the impact of single-molecule localisation microscopy (SMLM) in understanding disease mechanisms, improving drug discovery, and advancing patient stratification. “This technology has transformed our approach to biomedical research, revealing insights that were previously inaccessible,” said Lorenzo Albertazzi, Associate Professor at TU/e’s Department of Biomedical Engineering.

ONI designed the Aplo Scope as part of the Aplo Platform - an integrated solution combining application-specific kits and cloud-based software. By streamlining workflows and enhancing data analysis, ONI continues its mission to make super-resolution microscopy both powerful and accessible, helping scientists uncover the molecular foundations of health and disease.

More information online