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The Human Protein Atlas (HPA), a Sweden-based program founded in 2003 which aims to map all the human proteins in cells, tissues and organs, has selected Horizon’s CRISPR-edited knockout cell models to advance understanding of the genetic drivers of disease. Knockout cell models offer the possibility for an enhanced validation of antibodies based on genetic strategies, because the complete absence of the targeting protein correlates with a complete loss of signal for specific antibodies.
The growing information database of HPA is available as open access to scientists in academia and industry to explore the human proteome. Its Cell Atlas program, which details the subcellular localisation of proteins in single human cells, provides high-resolution insights into molecular mechanisms.
Professor Emma Lundberg, responsible for the HPA Cell Atlas program, explained: “Horizon has over a decade of experience in gene editing and a well-established reputation for providing CRISPR-edited knockout cell models. We have previously used Horizon’s cell lines in our high throughput imaging processes with great success. Using a validated gene-edited cell line where all cell models have the same background will be key to maximising efficiency and achieving data reproducibility.”
Terry Pizzie, CEO, Horizon Discovery, said: “Having contributed to several thousands of publications in the field of human biology and disease, the HPA is a highly regarded knowledge provider and an expert in the field of molecular mechanisms of the human cell. We are delighted to partner with HPA to provide the robust research tools required to extend their database and we are proud to be contributing to the expansion of this renowned open access resource for both academia and industry.”
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