• Leeds Research Finds new Piece of BSE Puzzle

News & Views

Leeds Research Finds new Piece of BSE Puzzle

A new treatment route for bovine spongiform encephalopathy (BSE) and its human form Creutzfeldt Jakob disease (CJD) could be a step closer thanks to a discovery by scientists at the University of Leeds who have discovered that protein Glypican-1 plays a key role in the development of BSE.

BSE is known to be caused by an infectious and abnormal form of the prion protein which is present on cells within the nervous system. But scientists have been unclear as to what causes the prions to become abnormal.

The new research from Leeds’ Faculty of Biological Sciences shows that the presence of Glypican-1 causes the numbers of abnormal prion proteins to rise. In experiments, when levels of Glypican-1 were reduced in infected cells, the levels of the abnormal prion reduced as well.

The discovery was a mixture of scientific detective work and luck, according to Professor of Biochemistry, Nigel Hooper.

“We were looking at how the normal prion protein functions in cells and spotted that it was interacting with something,” he said. “Some lateral thinking and deduction led us to Glypican- 1 and when we carried out the experiment, we found we were right.”

The team believe that Glypican-1 acts as a scaffold bringing the two forms of the prion protein together and that this contact causes normal prions to mutate into the infectious form. They are seeking further funding to investigate their hypothesis.

“Now that we know the identity of one of the key molecules in the disease process, we may in the future be able to design drugs that target this.”

While initial experiments haven’t shown any link with other neurodegenerative diseases like Alzheimer’s, we’re not yet completely ruling that out,” said Professor Hooper.

The research is published in PLoS Pathogens (Nov 20).and was mainly funded through the Wellcome Trust with additional support from the Medical Research Council.


Digital Edition

Lab Asia 31.6 Dec 2024

December 2024

Chromatography Articles - Sustainable chromatography: Embracing software for greener methods Mass Spectrometry & Spectroscopy Articles - Solving industry challenges for phosphorus containi...

View all digital editions

Events

Turkchem

Nov 27 2024 Istanbul, Turkey

Smart Factory Expo 2025

Jan 22 2025 Tokyo, Japan

Instrumentation Live

Jan 22 2025 Birmingham, UK

SLAS 2025

Jan 25 2025 San Diego, CA, USA

Arab Health

Jan 27 2025 Dubai, UAE

View all events