Microscope Provides Advances in Small Animal and In Vivo Imaging

The iBox Explorer2 Imaging Microscope detects fluorescent markers from whole mouse to individual cell level for in vivo imaging in immunology, stem cell biology, neuroscience and cancer biology research applications. Applications include tumour shedding, tumour growth and tracking, biodistribution, metastases Haematogenous and Intralymphatic trafficking and extravasation.

The integrated optics are designed to transition from the macroscopic to the microscopic scale, with deeper interrogation of a fluorescent signal in real time. Magnification range is from 0.17x to 16.5x.  Scientists imaging whole animals for tumour tracking or biodistribution will be able to ‘dive deeper’ into the animal in order to investigate biological phenomena at the cellular level.

The iBox Explorer utilises a BioLite™ Xe MultiSpectral Light Source which provides bright illumination for multispectral fluorescent, visible and NIR excitation. The BioLite Xe houses a 150-watt xenon lamp that supplies brilliant excitation of fluorescent probes for a variety of applications. The BioLite Xe includes an eight-position emission filter wheel for placement of filters and convenient switching between experiments and multiplexing applications. 

The system captures detailed images of tissues and cells with the leading-edge cooled scientific grade CCD camera. VisionWorks® software automates research with total system control and allows easy creation of templates for reproducible and consistent results. The system a computer/monitor loaded with the software.

Additional features include a built-in warming plate maintains a uniform temperature of the mouse. The plate slides out for easy access. A port in the darkroom allows access for an optional anaesthesia system.

UVP’s BioImaging Systems are available through a world-wide dealer network. Contact UVP for product or dealer information.