• New Mass Spec Solution Simplifies Analysis of Macromolecular Complexes
    The Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap MS powered by the Thermo Scientific Direct Mass Technology mode.

Mass Spectrometry & Spectroscopy

New Mass Spec Solution Simplifies Analysis of Macromolecular Complexes

New solution enables simultaneous charge detection for analysis of previously unmeasurable analytes

An innovative mass spectrometry solution from Thermo Fisher Scientific Inc provides proteomics and biopharmaceutical laboratories, working in drug discovery and R&D applications, the ability to clearly decipher complex mixtures of large macromolecules.

The Thermo Scientific Direct Mass Technology mode augments Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap mass spectrometers with charge detection capabilities, allowing direct mass determination of hundreds to thousands of individual ions in a single spectrum. As a result, laboratories can measure mass for complex heterogeneous mixtures of multiple charged components, unlocking new and rich insights into proteoforms, biotherapeutics and next-generation drug modalities.

“Direct Mass Technology mode combines charge detection with our trusted high-resolution accurate mass Orbitrap measurements to achieve results unattainable by current ensemble measurement techniques,” said Iain Mylchreest, Vice President, Research and Development, Analytical Instruments, Thermo Fisher Scientific. “By dissolving the complexity barriers inherent to other approaches, we’re enabling a wealth of investigations that were once firmly out of reach - from resolving heavily modified proteoforms to revealing small changes in large antibody-drug conjugate complexes, to name but a few.”

Neil Kelleher, Director, Northwestern Proteomics & the Chemistry of Life Processes Institute, Northwestern University, said: “The differences seen when moving from traditional mass spectrometry to this game-changing direct mass technology are profound. We’ve gone from having no data or uninterpretable data to having rich spectra laying bare proteoform complexity. With such solutions, we no longer need to be overwhelmed by the complexity of the human proteome. This technology makes clear that, ultimately, we can build tools that match the complexity and scale of our biology.”


Digital Edition

Lab Asia 31.6 Dec 2024

December 2024

Chromatography Articles - Sustainable chromatography: Embracing software for greener methods Mass Spectrometry & Spectroscopy Articles - Solving industry challenges for phosphorus containi...

View all digital editions

Events

Smart Factory Expo 2025

Jan 22 2025 Tokyo, Japan

Instrumentation Live

Jan 22 2025 Birmingham, UK

SLAS 2025

Jan 25 2025 San Diego, CA, USA

Arab Health

Jan 27 2025 Dubai, UAE

Nano Tech 2025

Jan 29 2025 Tokyo, Japan

View all events