New Screening Compound Library

Thermo Fisher Scientific, Inc announced Maybridge HitFinder™-Plus, a collection of 3,000 pre-plated drug-like
screening compounds that is ideal for a variety of drug discovery programs. The new library expands the industry
leading Maybridge HitFinder collection of 14,400 screening compounds and is available as an ‘add-on’ for
current HitFinder users at reduced upgrade fees.

Thermo Fisher created the new HitFinder-Plus collection using an industry standard clustering algorithm, based on
standard Daylight Fingerprints and a Tanimoto level of  0.55, to select a statistically representative sample of the
full 56,000 compound Maybridge Screening Collection. All compounds fit Lipinski Ro5 guidelines for ‘drug-likeness’
and have a purity level of greater than 90%. They have also been selected to be non-reactive, ensuring fewer false
positives and higher-quality results.

When combined, the pre-plated Maybridge HitFinder and HitFinder-Plus collections contain more than 17,400
unique drug-like screening compounds, providing a large, but manageable library that is flexible enough for a range
of drug discovery programs. These pre-selected, diverse collections are conveniently supplied as dry films in
Thermo Scientific Matrix 96-shallow-well plates or 384- well microplates. For further convenience, users can view
 nd assess the exact structures in each plate by browsing the collections online. This ensures that the process of
identifying potential drug leads using Maybridge compounds is as easy and cost-effective as possible.