Trace level quantitation of Multiple Compounds

Shimadzu’s LCMS-8050 triple quadrupole LC-MS/MS meets the growing demand for trace-level quantitation in clinical research and other markets. It incorporates proprietary ultrafast technologies as well as a newly developed ion source and collision cell technology. As the flagship model of Shimadzu’s UFMS (Ultra-Fast Mass Spectrometry) product line, the LCMS-8050 features high sensitivity, high data quality and the world’s fastest data acquisition rates.

Delivering attogram-level (10^-18 grams) sensitivity and possessing unsurpassed ruggedness, the LCMS-8050 achieves its improved sensitivity through two important technologies: newly designed Heated ESI source improves desolvation and enhances ionisation efficiency with the addition of a heated gas used in combination with the nebuliser gas; UFsweeper^®III collision cell enhances CID efficiency by optimising the collision cell pressure.

The newly engineered high voltage power supply enables a maximum scan rate of 30,000 u/sec and a 5 msec polarity switching time, making the LCMS-8050 combined with Nexera UHPLC the ideal platform for laboratory productivity. It is now possible to include 1,000 events with up to 32 channels per event for a maximum of 32,000 MRMs per analysis.

The instrument features user-friendly operation and is easy to maintain. The plug-in for the new ion source enables easy changing from ESI to APCI or to dual ionisation mode (DUIS). LabSolutions LCMS Version 5.60 software provides seamless integration of HPLC and MS control. An automated MRM optimisation routine allows unattended optimisation of multiple compounds.