York funding boost for Cryo-EM Equipment

The University of York’s Department of Chemistry has been awarded £1.6million to invest in equipment used to investigate the three dimensional structures of biological molecules.

The funding, which will be used to invest in cryo-electron microscopy (Cryo-EM) equipment , was awarded by the Wellcome Trust. Cryo-EM is a form of microscopy used by structural biologists in which biological samples are flash frozen to extremely low temperatures allowing them to be studied in the electron microscope in their native states –how they exist within a living cell.

Cryo-EM is transforming areas of science essential for improving health, from seeing how drugs get into cells or visualising the atomic-level structure of a virus to aid vaccine development. The funding will allow scientists to address important biomedical questions that were simply unanswerable a few years ago.

Professor Gideon Davies, from the Department of Chemistry, said: “Cryo-electron microscopy is one of the most exciting developments of recent years. We are extremely grateful for the generosity of Tony Wild and the Wellcome Trust in funding this initiative. We are looking forward to analysing the complex atomic structures of viruses and of proteins involved in human disease here in York."

Professor Keith Wilson, from the Structural Biology Laboratory at York, said: "Every now and again, there are technological advances that are both unexpected and disruptive, and that have a profound effect on the way that a key area of science is done. This is the case with cryo-electron microscopy for looking at biological structures, which is one of the most exciting developments of recent years.”

Head of Department Professor Duncan Bruce added: “To have been able to acquire this technique in York underpins further the world-class structural work for which we are well known and I very much look forward to the exciting science that will follow.”