Analysis of Oligonucleotides and their Related Substances

Oligonucleotides are growing in importance in the pharmaceutical and biotechnology industries as therapeutic medicines to address significant medical needs that are so far unmet. Over the past decades, research into synthetic oligonucleotides as therapeutic medicines has grown as they have the potential to be used as highly targeted medicines to treat a range of diseases, particularly genetic disorders.

However, oligonucleotides are a unique class of molecules and their structure and analysis make them one of the most challenging tasks for analytical chemists, and thus require a different approach to existing medicinal products. 

For successful research and development, it is necessary to acquire new skills and knowledge in the field of oligonucleotides analysis. This book, Analysis of Oligonucleotides and their Related Substances, provides various analytical technologies that are in frequent use in modern research and reviews the most up-to-date analytical strategies for synthetic oligonucleotides. 

Subdivided into seven chapters, it discusses the importance of characterising impurities in oligonucleotides, the different chemical classes, and their synthetic origins. It also focuses on current analytical methodologies and strategies for characterising synthetic oligonucleotides using modern techniques in chromatography and spectroscopy. Readers are provided with a broad perspective and a wealth of current knowledge, while also being familiarised with actual instrumentation and case studies. This book will serve as an invaluable reference tool by giving guidance and tried-and-tested approaches for characterising oligonucleotides.

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