Digital Dispenser Simplifies SPR Experiments

The Structure and Biophysics department at AstraZeneca R&D Mölndal, Sweden, is reaping the benefits of a recently acquired HP D300 Digital Dispenser for surface plasmon resonance (SPR) studies, saving time, enhancing consistency and using significantly less compound for dose-response experiments. Principal Scientist Stefan Geschwindner explained: “The need for the HP D300 Digital Dispenser was largely driven by a demand for more effective SPR studies and increased flexibility. We already had an acoustic dispenser, but this was not ideal, as there are peaks and troughs in our work, and we needed an economical solution that could accommodate these changing demands. Tecan provided an instrument for us to try, and people immediately saw the benefits, realising that the HP D300 could really change our way of working, helping to generate data more rapidly and shorten lead times.”

“The HP D300 is very easy to use and saves us so much time. It gives us the flexibility to use very low concentration stock solutions and perform different dilution patterns, and the instrument does all the calculations for us. Another big advantage is that we save a lot of material, which is particularly important when the amount of compound available is limited. The HP D300 can even recover any solution that has not been dispensed, which is brilliant. The savings are tremendous and, other than manual pipetting, this is probably the only effective way to prepare our dose-response curves.”

To find out more about the HP D300 Digital Dispenser, visit  www.tecan.com/digitaltitration.