Detecting Sub-Nanometre Molecules at Low Concentrations

Avid Nano have issued a new technical note demonstrating the excellent performance of its W130i Dynamic Light
Scattering System for detecting and precisely measuring subnanometre particles and molecules.

The new technical note describes the ease with which a very small molecule with a low molecular weight (caffeine, MW
194.2 g/mol) was accurately measured at only 1.4% concentration in aqueous solution. The results using the W130i DLS demonstrate that the light scattering signal from the dissolved caffeine is sufficient to produce a good quality correlogram with an intercept >0.2 and  highly reproducible data with low polydispersity. The mean radius was consistently reported at about 0.48nm and molecular weight estimate around 400Da indicating concentration dependent self association into dimers, a known characteristic of caffeine in aqueous solutions. Engineered to
meet the demands of today's research laboratories, the W130i dynamic light scattering system delivers outstanding performance from only microlitres of sample in seconds. The W130i combines ultimate measurement performance with an economical benchtop footprint, rugged durability and supreme user convenience.