HPLC Simplicity with UPLC Performance

Waters Corporation introduced the new Waters® ACQUITY UPLC® H-Class System incorporating the proven, robust and reliable performance of ACQUITY UltraPerformance LC® (UPLC) with the operational familiarity of traditional high performance liquid chromatography. This combination of performance, simplicity and flexibility is designed to help more laboratories realise the scientific and business benefits of sub-2-μm (micron) particle column technology by making it more accessible to a broader range of industries, applications and operators. With systems currently installed in Waters’ demonstration laboratories worldwide, the ACQUITY UPLC H-Class is ready for customer shipping today. Beyond improving chromatographic performance when running UPLC columns as well as fully supporting HPLC columns, the ACQUITY UPLC H-Class system closely emulates HPLC workflows, making method transfer from HPLC to UPLC easier and more seamless. Furthermore, the introduction of the ACQUITY UPLC H-Class allows organisations to standardise their
approach to LC with a common technology platform that makes the future transition from HPLC- to UPLC-based methods straightforward and practical - from product discovery to product release testing.

The answer to achieving UPLC performance and benefits without fundamentally modifying HPLC workflows came in the form of the ACQUITY UPLC H-Class’ new quaternary solvent manager (QSM) and sample manager (SM-FTN), with flow-through needle design, thereby mimicking traditional HPLC system workflow. The featured QSM and SM-FTN on the ACQUITY UPLC H-Class combine to enable the chromatographer to achieve high separation efficiency using sub-2-μm (micron) particle separations at high pressures. The result is seamless upgrade of chromatographic capabilities.