Next-Generation Triple Quadrupole Mass Spectrometers Deliver High Precision for Quantitative Workflows

Analytical laboratories can now obtain high quality data with new triple quadrupole mass spectrometry technology designed to provide exceptional performance for the most demanding targeted quantitation applications in the environmental, food safety, pharmaceutical and biopharmaceutical industries as well as clinical research and forensic toxicology.

The new TSQ Altis and TSQ Quantis Triple Stage Quadrupole mass spectrometers offer outstanding robustness and sensitivity for demanding targeted quantitation assays.

“Laboratories worldwide are under increasing pressure to answer complex analytical questions, while still meeting evolving regulatory, business and scientific goals,” said Evett Kruka, Vice President and General Manager, Life Sciences Mass Spectrometry, Chromatography and Mass Spectrometry, Thermo Fisher. ”Our newest generation of triple quadrupole mass spectrometers is designed to deliver reproducible, reliable quantitation results for nearly all molecule types in complex matrices, even by less experienced users.”

The TSQ Altis Triple Stage Quadrupole mass spectrometer offers sensitivity, selectivity and speed while providing the analytical flexibility and reproducibility for demanding applications. The TSQ Quantis Triple Stage Quadrupole mass spectrometer is designed to be a quantitative workhorse, supporting reliable workflows that combine ease of use with the highest possible data.

The TSQ Altis and TSQ Quantis systems are engineered to deliver unique, high-resolution single reaction monitoring (SRM) capabilities, which enables ion transmission and consistency for reproducible results across instruments. In addition, both systems are equipped with Active Ion Management (AIM+) technology that includes redesigned ion source housing, segmented quadrupoles, new RF electronics and an enhanced dual-mode electron multiplier detector for ultimate ion management from ion inception to detection. AIM+ technology offers superior reproducibility, sensitivity, more data points with fast SRM rates and increased detector lifetime when compared to previous AIM technology and other triple quadrupole mass spectrometry systems.

“With the new Thermo Scientific TSQ Altis mass spectrometers, my lab can develop quantitative methods for biotherapeutic proteins and target receptors with extreme sensitivity, selectivity, accuracy and precision,” said Dr Jun Qu, Associate Professor, department of pharmaceutical sciences, University at Buffalo in New York.

The instrument control software for the TSQ Altis and TSQ Quantis Triple Stage Quadrupole mass spectrometers offers automated compound optimisation and new tools for streamlined, intuitive method setup. When combined with Thermo Scientific TraceFinder Software, a workflow software that addresses critical requirements from sample introduction to report generation, analytical scientists can improve the targeted quantitation analysis of complex molecule types with simplified workflows, reducing the time to generate high quality results when compared to using the instrument control software alone.