Liquid Handling Solutions for Successful Cell Culture Workflows

How shearing force affects cell viability and reproducibility

Many vital stages in the cell culture workflow require handling or mixing solutions with a pipette but, if not done with care, this can lead to the shearing of cells at the orifice of the tip. Exposing cells to shearing forces can result in cell lysis and cell death, significantly reducing cell viability and reproducibility. 

New series offers guidance for improved cell viability 

Integra Biosciences offers a full range of electronic pipettes, pipetting robots and media dispensers tailored to allow gentle pipetting for cell-based liquid handling tasks. This equipment is designed to offer enhanced pipetting speed control, limiting the stress placed on cells during handling to improve cell viability. In the first of its cell culture series, Integra tackles the challenge of cell viability, offering guidance for choosing the correct tools to optimise cell culture techniques. 

Liquid handling solutions for reproducible, healthy cells

Experts at Integra have developed an extensive range of liquid handling products - from multichannel electronic pipettes to assisted robotic platforms - to help scientists reproducibly culture healthy cells. Electronic pipettes give scientists greater control during cell handling, ensuring consistent, clearly defined pipetting speeds to minimise shearing forces and reduce the influence of user technique as a potential source of variation. The company also offers its renowned GripTip pipette tips in various sizes and styles, including wide bore options with a larger orifice for cells to flow through, further reducing the shearing forces. These innovations are based on years of experience and an appreciation of customers’ needs, ensuring the company remains an all-around trusted supplier and partner for cell biologists. 

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