Debut of Exactive Benchtop LC-MS

Thermo Fisher Scientific, Inc debuted its new Thermo Scientific Exactive, a benchtop liquid chromatography-mass spectrometry (LC-MS) system designed for high-throughput and highperformance screening and compound identification applications, at PITTCON 2009. The Exactive™ system leverages the company’s proven Orbitrap™ mass-analyser technology, the recognised standard for accurate mass and high-resolution measurement, to provide precise and reliable information. It is fast, easy to use, cost effective to operate and, coupled with workflow-driven software, makes an ideal instrument for new users in routine analytical laboratories.

The Exactive LC-MS improves laboratory efficiency and throughput by streamlining many of the technical steps that normally require specialised set-up and operation. An intuitive software interface makes the system easy to use in both expert and ‘walk-up’ mode, while ensuring precise mass identification of target compounds over a wide concentration range. While simple to operate, Exactive sets new standards for LC-MS performance at resolutions of up to 100,000. When combined with excellent single-scan mass accuracy in positive and negative modes, Exactive is the ideal LC-MS system for accurate, high-throughput screening and compound identification.

“Our Thermo Fisher Orbitrap technology has been an important driver of LC-MS growth in the world of biology,” said Lester Taylor, Marketing Director, mass spectrometry, at Thermo Fisher Scientific. “We asked ourselves what we could do to fully realise the potential of this technology to make it even more accessible to users with routine toxicology, environmental and drug-development workflows. The answer is Exactive – an instrument we consider a real breakthrough that can be applied to a great number of challenging new applications.”

The Exactive system’s Pathfinder software provides the right workflow for the right analysis, enabling experienced users to tune and optimise the system, develop methods and perform a wide range of experiments. New users and non-mass spectrometrists can easily follow developed methods to get analytical answers quickly and automatically. If necessary, both levels of users can then jointly utilise
Pathfinder’s data review capabilities to dig deeper into the wealth of data that the Thermo Scientific Exactive system provides.