Rapidly Identifying Proteins Associated with Neurodegenerative Diseases

Syngene is delighted to announce that its Dyversity 2D imaging system is being used by one of Europe’s leading research institutes, the University of Lausanne in Switzerland, to help identify proteins associated with
neurodegenerative diseases.

Scientists in the Centre for Psychiatric Neurosciences at the University of Lausanne are using a Dyversity imaging system to analyse differential 2D gel electrophoresis (DIGE) acrylamide gels of brain proteins labelled with different Dyomics fluorescent dyes including maleimide dyes with wavelengths between 400nm to 700nm. This is allowing the researchers to determine the mechanisms affecting protein composition during neurodegeneration, which they believe will help them identify disease specific markers and define their role in disease progression.

Professor Beat Riederer said: ”To image the labelled gels we use the Dyversity system because it allows imaging of three or more samples separated on the same 2D electrophoresis gel and by overlaying each protein pattern we can subsequently locate differences in protein composition. We have been very happy with the Dyversity system because it has met our expectations and enabled us to rapidly analyse our gels and locate some very interesting proteins.”

Laura Sullivan, Syngene’s Divisional Manager stated: “Their impressive results are excellent proof that our well-designed CCD imager can process labelled DIGE gels much more rapidly than laser scanning technology and shows the Dyversity system is essential for any laboratory needing to significantly increase throughput in their proteomics research.”