• Biopharmaceutical Portfolio Based on Bioencapsulation Technology

Laboratory Products

Biopharmaceutical Portfolio Based on Bioencapsulation Technology

Q Chip is developing a range of sustained-release biosimilars using its patented Q-Sphera™ bioencapsulation platform. Q-Sphera is an enabling technology for peptide and protein delivery and a lower cost formulation and production platform for biosimilars.

The first two drugs under development using the Q-Sphera delivery system are the biosimilars, Q-Leuprolide (primary indications in prostate cancer and endometriosis) and Q-Octreotide (primary indications in acromegaly, and palliative care). Q-Leuprolide and Q-Octreotide are three- and one-month sustained release microsphere formulations respectively. Q Chip’s Q-Sphera technology offers several potential solutions to overcome the issues with biotherapy delivery, most notably via minimisation of protein and peptidal degradation and lower cost of production. The Q-Sphera drug-loaded microspheres are produced using bioresorbable polymers, and at 80 microns in diameter are injectable using 27-29 needle gauge devices.

Encapsulation of biotherapies into bioresorbable microspheres enables sustained and improved drug delivery. Q-Sphera is manufactured using Q Chip’s established bio-encapsulation platform, which eliminates many of the limitations of conventional pharmaceutical microencapsulation methods. In particular, Q-Sphera microparticles are monodisperse with a CV (coefficient of variance) of less than 2%. Particle size significantly influences drug release characteristics and there is a direct correlation between consistent particle size and consistent drug release and therapeutic performance. Q-Sphera microspheres also typically have a high drug load with a correspondingly high activity. Q-Leuprolide and Q-Octreotide are in pre-clinical phase with bioequivalence studies planned for completion in 2011.


Digital Edition

LMUK 49.7 Nov 2024

November 2024

News - Research & Events News   - News & Views Articles - They’re burning the labs... Spotlight Features - Incubators, Freezers & Cooling Equipment - Pumps, Valves & Liquid Hand...

View all digital editions

Events

analytica China

Nov 18 2024 Shanghai, China

Pharma Asia

Nov 20 2024 Karachi, Pakistan

Turkchem

Nov 27 2024 Istanbul, Turkey

Smart Factory Expo 2025

Jan 22 2025 Tokyo, Japan

Instrumentation Live

Jan 22 2025 Birmingham, UK

View all events