Library Maintenance for the Smaller Pharma

An application note from Genevac describes how their Model DD-4X centrifugal evaporator has been used by a pharmaceutical company to address the sample integrity and physical storage problems associated with compound library maintenance.

Entitled ‘Library maintenance for the smaller pharma’ the application note details a high throughput process to produce compound libraries as dry films that have been validated for long-term storage. The authors describe how compounds were solubilised, reformatted from 96- to 384-well plates and then dried down using a Genevac DD-4X centrifugal evaporator for storage at room temperature. The high capacity of the Model DD-4X is shown to facilitate sample-safe evaporation of sixteen 384-well plates to dryness in only 25 minutes at 40ºC. The described dry film methodology reduces the time for compound preparation and produces enough assay ready sets of dry film plates for at least 10 screens.

The Model DD-4X from Genevac is an affordable, high-performance centrifugal evaporator system designed to handle the wide range of sample types and formats encountered in pharmaceutical laboratories.