HPLC Column Separates Wide Variety of Pharmaceutical Counterions

Thermo Fisher Scientific is pleased to announce the expansion of the Acclaim™ Trinity™ family of HPLC column with new Acclaim Trinity P2 columns. The new columns are designed to screen a wide range of counterions, including cations, anions, mono and multi-valent ions with one analysis, thanks to advanced mixed-mode Nanopolymer Silica Hybrid (NSH™) technology. Simple LC screening of the Active Pharmaceutical Ingredients (API) and their counterions can be achieved with high sensitivity using the Thermo Scientific™ Dionex™ Corona™ Charged Aerosol Detector.

The chemistry is designed to provide spatial separation of the anion exchange and cation regions, resulting in greater resolution and selectivity control. Also, the particles’ hydrophilic surface makes the Acclaim Trinity P2 useful as a HILIC column. It provides cation exchange, anion exchange and HILIC retentions on the same stationery phase, helping customers develop robust, fast, generic methods to improve productivity and reduce cost.