Biotage breaks new ground with its fully integrated mass directed flash system

The Biotage Isolera™ Dalton - a fully automated miniaturised mass directed flash purification system. The new system raises the bar for flash purification by integrating, for the first time, a miniaturised mass detector and an advanced flash chromatography system into one commercially available platform.

The mass detector and Isolera™ Spektra flash purification system are seamlessly integrated via the Isolera™ Dalton Nanolink unit, an intelligent sampling device which handles all fluids and synching calculations between the two units. Isolera™ Dalton easily fits inside a standard fume hood, requires no external pumps and is capable of both normal and reverse-phase separations, so it is completely compatible with the diverse purification needs of the modern research laboratory.

This combination of identification and purification removes complex off-line analytical steps from the workflow, vastly increasing throughput and putting the entire purification and analysis in the hands of the chemist. Reactor content can be injected directly to identify target masses, which then are transferred directly to the Flash method for mass targeted purification.

“Compounds are identified in real time during purification and this informs the flash fractionation process, enabling the correct product to be collected by the system. The system automatically accommodates different column sizes and flow rates, overcoming major issues with simple splitter-based systems.  Isolera™ Dalton significantly reduces the number of steps required to purify and confirm a target compound, thus improving workflow and increasing confidence that chemists have synthesized what was intended. Quite frankly there is nothing else like it on the market today or that even comes close,” says Dr Greg Saunders, Regional Market Manager, Biotage.

The instrument uses a wizard-based approach to method development, simple on screen prompts guides chemists through the system; even those whose expertise or priorities lie in compound synthesis rather than analysis. Isolera™ Spektra software with its graphic user interface provides a straightforward controlling environment, giving easy access to the process. Isolera™ Dalton Mass Detector uses a chip-based electrospray system with a miniaturised quadrupole and internal vacuum pumps, allowing the system to easily fit in a fume hood, and is capable of handling both normal and reverse-phase samples with ease. 

Advantages:

• Compound identification by mass during purification and by direct injection
• Fully automated integration of Flash purification and mass detection via the Isolera™ Dalton Nanolink
• Automatically accommodates different flash flow rates
• Simple wizard-based approach to method development
• Compact system with miniaturised mass detector, easily fits inside a fume hood with no external pumps.

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