Chromatography
How to Avoid Residual Solvent when Drying Reverse Phase HPLC Fractions
Mar 15 2016
Traditional concentration of reverse phase HPLC fractions to dryness in a Genevac HT evaporator is a fast and safe process. However, for certain compounds a fully dried result can be hard to achieve due to compound interactions with water boosting up the boiling point making drying difficult.
Driven in part by the compound handling groups rejecting samples that were not completely dry, Genevac responded with the development of a fast lyophilisation process, or Lyospeed™, (a hybrid drying process combining conventional centrifugal evaporation and lyophilisation). Customer feedback suggests that in up to 90% of cases, depending on the compound properties, the application of Lyospeed™ produced a dry powder rather than the traditional thin film, making downstream processing far easier since compounds could either be more easily removed from the tube of vial, or re-dissolved in a suitable solvent.
To read more, visit www.biopharma.co.uk/bps/about/blog/.
Digital Edition
International Labmate Buyers' Guide 2024/25
June 2024
Buyers' Guide featuring: Product Listings & Manufacturers Directory Chromatography Articles - Enhancing HPLC Field Service with fast-response, non-invasive flowmeters - Digital transformatio...
View all digital editions
Events
Jul 03 2024 Gandhinagar, India
Jul 07 2024 Dublin, Ireland
Jul 20 2024 Denver, CO, USA
Jul 21 2024 Cape Town, South Africa
Jul 28 2024 San Diego, CA USA