Comprehensive characterization of proteoforms with icIEF-UV/MS
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Mass Spectrometers
Collect the data for comprehensive charge variant ID in minutes not weeks.

Comprehensive proteoform identification in minutes

The process of identifying individual charge variant components and interpreting their structural differences conventionally takes weeks and requires the use of multiple instruments, with multiple manual steps.

With the Intabio ZT system - separation, quantitation and identification of individual charge variants can be achieved in minutes on a single platform.

Charge heterogeneity analysis
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Request more information to learn how the Intabio ZT system can work for specific your needs.
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Leverage key analytical functions with microfluidic chip-based technology

The Intabio ZT cartridge enables key analytical functions using proprietary microfluidic chip-based integrated icIEF-UV/MS technology.

  • Separation of charge variants with imaged capillary isoelectric focusing (icIEF)
  • Quantitation with real-time UV detection
  • Electrospray ionization for further mass spectrometry identification

Separation of charge variants with imaged capillary isoelectric focusing (icIEF) and quantitation with imaged UV detection occurs within the separation channel

To enable electrospray ionization, electrolyte is introduced through the mobilizer channel near the ESI tip, to re-ionize the charge variants. The electric field is re-oriented to initiate the mobilization of the peaks toward the electrospray “ESI” tip. This novel chemical mobilization process ensures that peak resolution is maintained throughout MS detection.

Separated charge variants are introduced to the mass spectrometer by electrospray ionization for peak identification.

Eliminate the guess work with the ZenoTOF 7600 system

Enable a more detailed characterization approach by leveraging the enhanced capabilities of the powerful ZenoTOF 7600 system with EAD fragmentation technology.

Explore the ZenoTOF 7600 system

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Let Biologics Explorer software do the heavy lifting

Maintain data continuity with a single workflow producing one, accessible dataset, where UV peaks correlate with MS peaks. Let Biologics Explorer software do the heavy lifting with pre-built workflows for charge variant analysis. Get the required information to make confident decisions, fast.

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Contact SCIEX
Request more information to learn how the Intabio ZT system can work for specific your needs.
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Wherever you play in the pipeline, change the game in modern medicine

Clone selection, cell line development

Intact protein analysis, charge variant analysis, PTM characterization

Process development

Charge variants, glycoforms, PQA assessment

Formulation

Stability/degradation

Manufacturing attribute monitoring

CQA and PQA monitoring

Associated applications

Charge variant analysis

Achieve the full picture and accelerate decisions with comprehensive characterization of biopharmaceutical charge variants.
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Intact protein analysis

Confidently select lead candidates and ensure reproducible product quality. Fast and reliable protein analysis solutions that simplify identification and characterization of complex molecules at the intact level.
Learn more