Nature

Illustration showing a retro-futuristic scene with stacks of papers depicting buildings, with the papers at the top floating away

Exclusive: the most-cited papers of the twenty-first century

A Nature analysis reveals the 25 highest-cited papers published this century and explores why they are breaking records.

Pig livers for people: US regulator greenlights first safety trial

Four people with liver failure will be connected to an external organ from genetically modified pigs.

Rachel Fieldhouse
News15 Apr 2025
These are the most-cited research papers of all time

Some studies have received hundreds of thousands of citations, Nature’s updated analysis shows.

Richard Van Noorden
News Feature15 Apr 2025
Functional connectomics spanning multiple areas of mouse visual cortex

Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of thousands of neurons of a region of the primary cortex and higher visual areas.

The MICrONS Consortium
ArticleOpen Access09 Apr 2025
Daily briefing: Five lawsuits have been filed in response to NIH cuts — what now?

Scientific bodies, academics and state attorneys have filed five lawsuits against the US National Institutes of Health, with more likely to follow. Plus, physicists have a new estimate for the maximum mass of a neutrino and a planet was spotted falling into its host star.

Jacob Smith
Nature Briefing14 Apr 2025
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Current Issue10 Apr 2025

News & Comment

Don’t believe the hype — quantum tech can’t yet solve real-world problems

Investors and the public should know what quantum devices can and, more importantly, can’t do.

Joan Arrow

World View16 Apr 2025
Should I return to my home country after my PhD abroad?
Dyna Rochmyaningsih

Career Feature15 Apr 2025
The fight to keep big tech in check: digital researchers are in ‘David and Goliath’ battle
Amy Orben

World View15 Apr 2025
Pig livers for people: US regulator greenlights first safety trial
Rachel Fieldhouse

News15 Apr 2025
Science’s golden oldies: the decades-old research papers still heavily cited today
Richard Van Noorden

News Feature15 Apr 2025
These are the most-cited research papers of all time
Richard Van Noorden

News Feature15 Apr 2025
Exclusive: the most-cited papers of the twenty-first century
Helen Pearson
Heidi Ledford
Richard Van Noorden

News Feature15 Apr 2025

Latest Reviews & Analysis

- Early air-pollution activists fight against city smoke
  
  A 250,000-year-old footprint preserved in ash, and the effect of a polluted atmosphere on health and the economy, in our weekly dip into Nature’s archive.
  
  News & Views15 Apr 2025
- Twenty years of genome-wide association studies
  
  A powerful and unbiased way to identify links between genetic variants and biological traits has changed scientists’ understanding of complex diseases and how to treat them.
  
  Lorraine Southam
  Eleftheria Zeggini
  
  News & Views15 Apr 2025
- Lung signals drive cancer-associated blood clots
  
  Fatal blood clots can arise in people who have cancer. The discovery of a cue that underlies these clots offers a therapeutic target and a way to assess clot risk.
  
  Ana Luísa Correia
  
  News & Views15 Apr 2025
- Hunter-gatherers journeyed by sea to Malta
  
  Evidence reveals that people reached Malta 8,500 years ago. Hunter-gatherers made the long trip there 1,000 years before agricultural societies arrived.
  
  Dylan Gaffney
  
  News & Views09 Apr 2025
- Airborne microplastics enter plant leaves and end up in our food
  
  Evidence for a previously overlooked route for microplastics to enter crops and reach plant tissues has implications for ecology and human health.
  
  Willie Peijnenburg
  
  News & Views09 Apr 2025
- Cancer vulnerabilities exposed by finding interactions among DNA repair factors
  
  Research Briefing09 Apr 2025
- Docking stations in porous crystals unlock elusive molecular structures
  
  Hongyi Xu
  
  News & Views09 Apr 2025
- Photonic chips provide a processing boost for AI
  
  Anthony Rizzo
  
  News & Views09 Apr 2025
- A wetter ancient Arabia could have enabled easier intercontinental species dispersal
  
  Faysal Bibi
  
  News & Views09 Apr 2025

Latest Research articles

Prdm16-dependent antigen-presenting cells induce tolerance to gut antigens

Liuhui Fu
Rabi Upadhyay
Dan R. Littman
Article14 Apr 2025
Towards accurate differential diagnosis with large language models

Diagnostic reasoning using an optimized large language model with a dataset comprising real-world medical cases exhibited improved differential diagnostic performance as an assistive tool for clinicians over search engines and standard medical resources.

Daniel McDuff
Mike Schaekermann
Vivek Natarajan
ArticleOpen Access09 Apr 2025
Connectomics of predicted Sst transcriptomic types in mouse visual cortex

The authors use Patch-seq and electron microscopy datasets to relate synaptic connectivity to the transcriptomic cell type of different types of inhibitory neuron.

Clare R. Gamlin
Casey M. Schneider-Mizell
Staci A. Sorensen
ArticleOpen Access09 Apr 2025
Ultra-broadband optical amplification using nonlinear integrated waveguides

An integrated optical parametric amplifier with an ultra-wide bandwidth was implemented using geometrically optimized low-loss nonlinear rib silicon nitride waveguides including the demonstration of broadband all-optical wavelength conversion.

Ping Zhao
Vijay Shekhawat
Peter A. Andrekson
ArticleOpen Access09 Apr 2025
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.

Kimitoshi Kimura
Ayshwarya Subramanian
Vijay K. Kuchroo
Article09 Apr 2025

Since US President Donald Trump took office in January 2025, his team has made major changes to the federal government that have disrupted research and research institutions in the United States and beyond.

Collection 26 Feb 2025

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Science jobs

Full Professorship (W3) for Special Hematology (f/m/d)

The Medical Faculty Mannheim of Heidelberg University offers the position of a Full Professorship (W3) for Special Hematology (f/m/d) to be f...

Mannheim, Baden-Württemberg (DE)

Medizinische Fakultät Mannheim der Universität Heidelberg
Full Professorship (W3) for “Dermatology and Venereology- (f/m/d)

Full Professorship (W3) for “Dermatology and Venereology” (f/m/d) to be filled as of 01.10.2027. The professorship will represent the subje...

Mannheim, Baden-Württemberg (DE)

Medizinische Fakultät Mannheim der Universität Heidelberg
Senior Publisher, Applied Science Journals

Job Title: Senior Publisher, Applied Science Journals Location(s): Paris or London Application Deadline: 1st May About Springer Nature Group ...

London (Central), London (Greater) (GB)

Springer Nature Ltd
Senior Lecturer / Lecturer I / Lecturer II, Society Hub, HKUST(GZ)

Guangzhou

The Hong Kong Univeristy of Science and Technology (Guangzhou)
Guangdong Ocean University is Recruiting High-Level Talents Globally

Dean of Fisheries College, Leading Scholars, Outstanding Young Scholars, and Full-time Faculty

Zhanjiang

Guangdong Ocean University

Exclusive: the most-cited papers of the twenty-first century

Pig livers for people: US regulator greenlights first safety trial

These are the most-cited research papers of all time

Functional connectomics spanning multiple areas of mouse visual cortex

Daily briefing: Five lawsuits have been filed in response to NIH cuts — what now?

News & Comment

Don’t believe the hype — quantum tech can’t yet solve real-world problems

Should I return to my home country after my PhD abroad?

The fight to keep big tech in check: digital researchers are in ‘David and Goliath’ battle

Pig livers for people: US regulator greenlights first safety trial

Science’s golden oldies: the decades-old research papers still heavily cited today

These are the most-cited research papers of all time

Exclusive: the most-cited papers of the twenty-first century

Latest Reviews & Analysis

Early air-pollution activists fight against city smoke

Twenty years of genome-wide association studies

Lung signals drive cancer-associated blood clots

Hunter-gatherers journeyed by sea to Malta

Airborne microplastics enter plant leaves and end up in our food

Cancer vulnerabilities exposed by finding interactions among DNA repair factors

Docking stations in porous crystals unlock elusive molecular structures

Photonic chips provide a processing boost for AI

A wetter ancient Arabia could have enabled easier intercontinental species dispersal

Latest Research articles

Prdm16-dependent antigen-presenting cells induce tolerance to gut antigens

Towards accurate differential diagnosis with large language models

Connectomics of predicted Sst transcriptomic types in mouse visual cortex

Ultra-broadband optical amplification using nonlinear integrated waveguides

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

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How Trump 2.0 is reshaping science

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Science jobs

Full Professorship (W3) for Special Hematology (f/m/d)

Full Professorship (W3) for “Dermatology and Venereology- (f/m/d)

Senior Publisher, Applied Science Journals

Senior Lecturer / Lecturer I / Lecturer II, Society Hub, HKUST(GZ)

Guangdong Ocean University is Recruiting High-Level Talents Globally

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154 million lives and counting: 5 charts reveal the power of vaccines

A map of neural signals and circuits traces the logic of brain computation

How Trump 2.0 is slashing NIH-backed research — in charts

Recurrent humid phases in Arabia over the past 8 million years

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