Features and Benefits of a Triple Quadrupole Mass Spectrometer

Explore our advanced Triple Quadrupole Liquid Chromatography-Mass Spectrometry (LC-MS) systems designed to meet the highest standards in analytical performance. Our cutting-edge technology ensures high sensitivity, precision, and reliability for your most demanding quantitative analysis needs.

Achieve the Highest Confidence in Targeted Compound Detection and Quantitation with Leading Sensitivity 

With over five orders of linear dynamic range and high selectivity, the TSQ Plus triple quadrupole mass spectrometers meet diverse needs for targeted quantitative analysis. Enhanced acquisition speeds enable large-scale studies for method optimization or translational workflow development. The 5 millisecond polarity switching maximizes productivity with fewer experiments. For data confidence in complex matrices, the advanced features of the TSQ Plus triple quadrupole MS ensure high-performance targeted analysis.

Easy-to-use instrument software to simplify method creation and data acquisition

Instrument control software offers pre-built templates and direct importation of existing methods, along with Thermo Scientific mzCloud database integration and extensive method editing capabilities. These features enable you to quickly set up and refine methods, significantly improving productivity. Additionally, the intuitive instrument calibration routines simplify instrument checks by automatically determining and performing the necessary calibration procedures. This comprehensive approach ensures efficient and accurate analysis, enhancing overall workflow efficiency.

Innovative instrument solutions for targeted data acquisition experimentation

Meet today’s requirements and tomorrow’s challenges with innovative hardware features that deliver next-level experimental performance. The new active collision cell enhances low-mass product ion transmission, crucial for many routine analyses. Superior acquisition speeds and a new power supply enabling 5 ms polarity switching combine with proven robustness and reliability to ensure maximum productivity in the most complex matrices.

LC-MS/MS companion software for integrated productivity

Integrated LC-MS software offers advanced features to create single-reaction monitoring (SRM) assay tables with predicted parameters, ensuring precise experiment setup. It processes data to determine optimal conditions and efficiently handles targeted data with customized reporting. The Thermo Scientific Chromeleon Chromatography Data System (CDS) manages all aspects of lab operations, including instrument control, data acquisition, processing, and reporting. Chromeleon CDS ensures seamless integration across instruments and methods, boosting productivity and ensuring high-quality results.

Ionization and interface options to extend laboratory capabilities

Targeted sample analysis methods cover a broad range of compound classes and experimental requirements, so laboratories need various options to meet their needs. These options include rapid ionization from biological dried spots and alternative ionization sources. Differential ion mobility can also be used to overcome background interference and extend the dynamic range in ion analysis.

Which triple quad mass spectrometer is right for your laboratory?

Robust quantitative performance made simple

TSQ Fortis Plus Mass Spectrometer

Next-level performance, robustness, and reliability delivering exceptional value for high-throughput ion analysis and triple quad mass spectrometry.

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Accessible extended quantitative performance  

TSQ Quantis Plus Mass Spectrometer

Increased sensitivity and performance deliver confident ion analysis, precise quantitation, and reliable method development for high-throughput applications using triple quad mass spectrometry.

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Ultimate quantitative performance made possible

TSQ Altis Plus Mass Spectrometer

Innovative hardware and software advancements address your most demanding quantitative applications.
 

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Meet the TSQ Plus triple quadrupole mass spectrometers

Learn about the new hardware features driving next-level performance for targeted quantitation

The 40-year history of triple quadrupole development

The history of innovative triple quadrupole designs at Thermo Fisher Scientific

Tomorrow’s quantitation today – dynamic duo

The integrated process of connecting knowledge between method development and routine testing

Overcoming the challenges of anti-sports doping

Ludovic Bailly-Chouribery from LCH discusses how the TSQ Altis and Altis Plus MS increase his productivity for anti-sports doping

Routine quantitation for genotoxic impurities

Alan Potts from Patheon discusses the robust and reproducible performance of the TSQ Fortis and Fortis Plus MS to meet the needs for customer requests

Meet the TSQ Plus triple quadrupole mass spectrometers

Learn about the new hardware features driving next-level performance for targeted quantitation

The 40-year history of triple quadrupole development

The history of innovative triple quadrupole designs at Thermo Fisher Scientific

Tomorrow’s quantitation today – dynamic duo

The integrated process of connecting knowledge between method development and routine testing

Overcoming the challenges of anti-sports doping

Ludovic Bailly-Chouribery from LCH discusses how the TSQ Altis and Altis Plus MS increase his productivity for anti-sports doping

Routine quantitation for genotoxic impurities

Alan Potts from Patheon discusses the robust and reproducible performance of the TSQ Fortis and Fortis Plus MS to meet the needs for customer requests


 

To perform quantitation assays with confidence, you need a liquid chromatography mass spectrometry (LC-MS) workflow solution that is relevant to your goals

White Paper: Sensitivity and acquisition speed with triple quadrupole technology

Today’s analytical methods performing routine quantitation continue to evolve to meet new environmental and health risks. Experimental methods are modified to include more compounds measured at lower detection levels with faster gradients to address throughput. Therefore, specific LC-MS/MS performance characteristics are critical to evaluate productivity.

 Download white paper ›

White Paper: Triple quadrupole mass spectrometer portfolio

Learn about the hardware and software innovations implemented in the TSQ triple quadrupole mass spectrometer platform to address the current and future challenges in targeted quantitation.  The platform enhancements enable ultimate confidence in data quality with robust, reproducible, and reliable quantitative methodologies.

 Download white paper ›

Lab-Forward Trade-In Program

We’ve made trading in your current chromatography, discrete analysis, elemental analysis, sample preparation, and mass spectrometry instruments faster and easier.

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LC-MS webinar series

Our webinar series expands your application knowledge for pharma, biopharma, environmental, omics, food, forensics and clinical research and more.

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