News

I WANT TO SEE THE APPLICATIONS In the realm of pharmaceuticals, precision and purity are paramount. Anastrozole, a potent aromatase inhibitor, holds immense significance in the treatment of…

Webinars

Continuous CPC header
Continuous CPC Webinar With Arpad Konczol. Watch the Recording Now! RotaChrom’s Lead Scientific Officer Arpad Konczol recently did a webinar presentation detailing continuous chromatography, and how you can…

Events

RotaChrom Technologies was invited to a prestigious event organized by the Budapest HEPA Hungarian Export Promotion Agency, to take part in an event for building connections and showcasing…

What does RotaChrom do?

RotaChrom has developed the world’s first commercially available industrial scale centrifugal partition chromatography (CPC) platform. This technology revolutionized the purification industry by providing cost-effective commercial scale chromatographic solutions to Partners all over the world. RotaChrom is currently working with a broad array of industries including pharmaceutical, nutraceutical, health and beauty, and botanical companies, CROs, CDMOs, research and academia, and more in the Americas, Europe, China, India, and Asia.

Industrial scale chromatography

Effortless scale-up from mg to kg/day to promote continuous production of APIs and macromolecules, and to improve treatments

Chromatography for the pharma environment

Proven GMP-compliant equipment design. Innovative, sustainable, and efficient industrial scale LC-CPC chromatography for the pharma industry

Versatile purification systems for a wide range of COIs

Macromolecules, peptides, nucleotides, steroids, stereoisomers, high or low polar compounds, drug-like compounds, and natural compounds

From research to industry

Select between lab-scale, pilot-scale, or industrial-scale purification

95% purity

Use CPC for isolation, separation, and remediation

20 kg/day

High production potential

Recover 95% of the solvent

Cost-effective

Without silica gel

No more expensive silica gel or resign are needed. Capitalize on innovative, sustainable, and efficient industrial scale liquid-liquid only CPC separation.

Environmentally friendly

CPC generates significantly less hazardous waste compared to traditional chromatography, since 95% of the solvents can be recycled and recirculated into the system.

Unparalleled Adaptability

The CPC infrastructure can be adapted for a new purification project within hours. Reach your desired combination of yield, purity and throughput in isolation, separation, or remediation.

About
chromatography

Chromatography is the process of purifying and separating components from crude mixtures. A target compound may have ingredients that are useful, beneficial and are highly valuable for API development or commercially sold products, while others must be extracted through a delicate and thorough purification process.

Centrifugal partition chromatography (CPC) is a cost-efficient preparative liquid-liquid chromatographic technique with unique features, such as robustness and versatility. It is particularly suited for the large-scale fractionation and purification of crude natural products, macromolecules, peptides, nucleotides, steroids, stereoisomers, high or low polar compounds, drug-like compounds, and natural compounds.

RotaChrom’s proven GMP-compliant CPC equipment design is used in the pharmaceutical industry to analyze and purify drugs, and in the botanical industry to purify botanical oils. It is also highly involved in the downstream processing of foods, beverages, fragrances and fine chemicals. This CPC design offers flexible resolving power, so you can reach your desired combination of yield, purity and throughput in isolation, separation, or remediation.

RotaChrom Products

rotaChrom rCPC instrument

GMP rCPC

The GMP rCPC is designed to adhere to cGMP regulations according to Eudralex Vol. 4. The platform can be used for API-grade compound production and pilot-scale purification and research tasks in a pharmaceutical environment. It is possible to collect up to 9 COI fractions and 1 Impurity fraction.

rotaChrom iCPC instrument

Continuous CPC

The Continuous CPC platform is a continuous, multiple dual-mode, dual-rotor CPC platform. It consists of two interconnected GMP-rCPC devices, a preparative unit, and the control unit. Unlike the standard batch operational mode, it enhances throughput with its continuous injection mode, allowing for more efficient sample processing and multiple increase in production, beside low operational cost.

rotaChrom rCPC instrument

rCPC

The rCPC platform is designed to execute pilot scale purification tasks within a laboratory environment, making it ideal for any batch, smaller or larger, or campaign type of research work as well as continuous batch production. Test your product before rolling them out to the market.

rotaChrom iCPC instrument

iCPC

The iCPC is the largest serialized centrifugal partition chromatographic platform in the world, designed for industrial scale purification projects in continuous batch operation mode, with the capacity to process hundreds of kilograms per month of crude input material. Bid farewell to silica, and linear scale-up your production to kg/day with flexible, affordable, robust, future-proof chromatography.

rotaChrom pCPC instrument

pCPC

This tailor-made system pCPC by RotaChrom is a combination of iCPC and solvent preparation and recovery, and regeneration. It also delivers a proprietary automated biphasic solvent system preparation platform, providing a flexible and continuous feed to our iCPC instrument. Automate your complete purification process and make products that meet all standards.

rotaChrom pCPC instrument + HeiVap Platform

pCPC+HeiVap platform

pCPC combined with the Heivap platform is a complex solution: this fully integrated production system enables complete solvent handling solution besides the iCPC purification platform. Adapt it to your very needs to ensure you concentrate and refinish your target compounds without having to compromise.

RotaChrom Services

Feasibility study

A study run by RotaChrom’s laboratory with the Partner’s material to evaluate the possible outcomes and to prove the successful purification of the target compound by RotaChrom CPC technology.

Method development and optimization

Tailor-made methods are being developed and adapted on RotaChrom CPC systems for the individual matrices and compounds of interest, derived from our Clients.

Optional production scale pilot study

After a feasibility study in certain cases it is a recommended option to conduct a production scale pilot study with RotaChrom’s expert team to optimize future operational parameters and enhance potential yield and profit.

Factory design consultancy

Joint efforts with Clients to find the most effective and viable layout and factory setup. RotaChrom prior installation, details installation requirements and recommends optimal layout for the individual processes of the Client, while local safety specifications and regulatory requirements are applied and defined beforehand by the Client.

Maintenance service agreement

Regular preventive maintenance to ensure safe and reliable operation.

Contact Us

RotaChrom Technologies LLC | Industrial-scale Chromatography