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AutoChrom®

Method Development Software for the Chromatography Expert

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AutoChrom® Overview

Develop Chromatographic Methods in Less Time

ACD/AutoChrom helps experts develop chromatographic separations using QbD principles. It uses a workflow-based structure to streamline and track a project so you can:

  • Begin with reasonable starting conditions and columns
  • Define a strategy and implement it with help from software wizards and assistants
  • Automatically run experiments for screening and optimization
  • Model your separation in 1D, 2D, or 3D
  • Document the reasons for your decisions and database your projects for future learning
Benefits

Method-Development Tools and Project Management

Take a strategic approach

  • Start your project by predicting compound properties and building a development strategy
  • Work through the steps logically and move closer to optimization with every experiment

Manage your project from start to documentation

  • Document your decisions for data integrity
  • Store the workflow alongside the experimental data and solutions
  • Upload everything to a searchable database so your team can find it again

Automate screening and optimization trials

  • Walk away, and AutoChrom Online will run your experiments automatically according to your strategy

Find optimal conditions by simulation

  • Optimize your separation in 1D, 2D, or 3D with color-coded resolution and suitability maps

Algorithmically track peaks between runs

  • Track a compound across multiple chromatograms by UV or MS spectra, with help from AutoChrom’s algorithms

Reduce unnecessary experiments

  • Cut down on experiments and development time with simulation and computer-assisted modeling

View your project from the dashboard. See the workflow strategy, the specific experimental steps, and your instrument configuration.

Customer Reviews
“Reliability, robustness, and lifetimes of methods have improved, and at the same time we have reduced the loss of interpretation information and expensive retesting of samples…the QbD approach to method development aided by ACD/AutoChrom provides return on investment within a short time.”

Rudy Sneyers
Janssen Pharmaceuticals

Product Features

Features of AutoChrom

  • Build a screening, optimization, and robustness-study workflow
    • Set parameters (solvent ratio, column, pH, gradient, temperature, and more) and levels to be screened and optimized
    • Automatically generate a corresponding list of experiments
  • Move through workflow waves with direction from workflow assistant
Deployment/Integration Options

AutoChrom Online vs. AutoChrom Offline

AutoChrom Online integrates with selected chromatography data systems (CDSs) to automatically run your experiments from your design—no manual copying of parameters needed.

AutoChrom Offline works with any instrument you might have. Get full access to all of AutoChrom’s method-development tools, while manually transferring your experiment parameters to your CDS.

With or without direct instrument control, AutoChrom significantly reduces the time it takes to develop new methods.

Compatible with All Your Instruments and Techniques

  • JEOL
More Reasons to Use AutoChrom

Why Take a Software-Assisted Approach to Method Development?

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Avoid the uncertainty of undirected, one-trial-at-a-time method development. By making a plan from the beginning, you reduce the chances of wandering the design space aimlessly and missing optima. Software can help by connecting your development strategy to actual experiments, then directly running those experiments and turning the data into a model for optimization. The project-management features will also help you document your choices for data integrity and justifiable decisions.

What's New!

What's New in AutoChrom v2024

  • Optimize the solvent ratio when the strong phase can be represented as a mixture of two predefined solvents (either pure or a mixture)
  • Execute experiments with OpenLab CDS 2.8
  • Improved visualization of Resolution and Suitability Maps with consistent coloring for failed calculations
Learn More about AutoChrom