Preparative HPLC Chromatography Systems
From Clinical to Commercial Manufacturing
As the drug pipelines become more diverse with complex and multiple products, these drive new manufacturing requirements. For instance,
- Complex molecules like oligonucleotides drive the need for high temperature processes
- Multiproduct facilities require flexible and easy to clean equipment
- Smaller batch sizes require compact equipment
The Hipersep® Flowdrive Platform is a family of preparative HPLC systems designed for the purification of peptides, oligonucleotides, insulin and other small molecules.
Hipersep® Flowdrive Platform
Find the Right Preparative HPLC System
The Hipersep® Flowdrive Platform offers highly sophisticated, easy-to-use equipment with a unique, compact design controlled by the Hipersep® SC software.
- High flexibility of configuration
- Sanitary configuration and design
- Compact & ergonomic design
- Large flowrate range
- Fully automated system
| Hipersep® Flowdrive Pilot | Hipersep® Flowdrive Process M | Hipersep® Flowdrive L | Hipersep® Flowdrive XL | Hipersep® Flowdrive XXL | |
|---|---|---|---|---|---|
Scale | Clinical Manufacturing | Clinical / Commercial Manufacturing | Clinical / Commercial Manufacturing | Commercial Manufacturing | Commercial Manufacturing |
Flow Rate Range | 6-90 L/hr | 60-500 L/hr or | 300-1000 L/hr | 500-1600 L/hr | 1000-2500 L/hr |
Max Pressure | 100 bars | 100 bars | 100 bars | 100 bars | 70 bars |
Typical Column Diameter | 50/80/110/150 mm | 110/150/200/300/450 mm | 450/590 mm | 590/800 mm | 800/1000 mm |
Certification and Explosion Proof | CE certification with optional ATEX Zone 2 | ||||
Hipersep® Flowdrive Pilot
The Hipersep® Flowdrive Pilot is a modular, compact and ergonomic system designed to minimize cross-contamination risk.
- Build in flexibility with over 1,000 possible configurations that integrate with columns from 50 to 150 mm ID
- Minimize risk of cross contamination with a sanitary, easy-to-clean concept
- Save facility space with a compact and ergonomic design
- Inlet pressure Booster Pump accessory available
Hipersep® Flowdrive Process M
The Hipersep® Flowdrive Process M is an innovative system with a pressure capacity of up to 100 bars and is compatible with high-temperature purification processes (up to 85°C), allowing for unmatched performance levels while meeting the stringent requirements of new pharmaceutical applications such as oligonucleotides.
- Achieve guaranteed and repeatable performance
- Obtain scale-up flexibility
- Get fast and easy cleaning validation
- Inlet pressure Booster Pump accessory available
Hipersep® Varicol: Multi-Column and Continuous HPLC
The Hipersep® Varicol is a multi-column, continuous chromatography concept particularly well-suited to large-scale separation of binary mixtures (e.g., enantiomers) and fractionation of other complex mixtures. This technology is designed to adapt seamlessly to users’ specific process requirements with guaranteed and repeatable performance.
- Achieve a robust continuous process
- Build a cost-effective and highly productive process
- Recycle up to 99.97% of solvent at commercial scale
Hipersep® Prochrom HPLC Chromatography Columns
Our columns meet high design standards, thus ensuring efficiency and scalability. DAC technology enables reproducibility and robustness over time.
